Characterization of Myocardial Infarct Size From 4D Ultrasound

This is a recording from a live webinar conducted on June 18, 2020, and presented by Arvin Soepriatna, PhD, postdoctoral researcher at the Center for Biomedical Engineering at Brown University in Rhode Island. Coronary artery disease remains the leading cause of death in the world. Despite a strong positive correlation between infarct size and mortality rates, longitudinal monitoring of infarct expansion remains challenging. A reliable, noninvasive and label-free method to quantitatively measure infarct size from 4D ultrasound data is therefore crucial in the study of infarct expansion.

In this presentation, two different methods to estimate infarct size, a strained-based and geometry-based approach, will be discussed. Taken together, the presented work provides an infarct sizing workflow that enables infarct expansion studies, an important component when assessing post-MI remodeling. Topics discussed during this webinar include: 4D ultrasound can be used to non-invasively capture the geometries of asymmetrical infarcts and its corresponding border zones, 3D strain mapping reveals a sigmoidal strain behavior at the interface of healthy and infarcted tissues, which can be used to estimate final infarct size, and pros and cons of the two approaches to infarct sizing: strain-based vs. wall-thinning.