Nov 19th, 2020

Editor Pick: Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid, Florian Puhm, Isabelle Allaeys, Abdallah Naya, Mounia Oudghiri, Loubna Khalki, Youness Limami, Nabil Zaid, Khalid Sadki, Rafiqua Ben El Haj, Wissal Mahir, Lamiae Belayachi, Bouchra Belefquih, Amina Benouda, Amine Cheikh, Marc-André Langlois, Yahia Cherrah, Louis Flamand, Fadila Guessous, Eric Boilard
Originally published 17 Sep 2020 | Circulation Research
Circresaha 120 317703 fig07

Abstract

Rationale:

In addition to the overwhelming lung inflammation that prevails in coronavirus disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2. Platelets are chiefly implicated in thrombosis. Moreover, they can interact with viruses and are an important source of inflammatory mediators. While a lower platelet count is associated with severity and mortality, little is known about platelet function during COVID-19.


Objective:

To evaluate the contribution of platelets to inflammation and thrombosis in patients with COVID-19.


The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318257