Basic Cardiovascular Science 2020 Scientific Sessions is supported by an independent medical education grant from: Merck and Novartis Pharmaceuticals North America.

Editor Pick: Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Originally published 17 Sep 2020 | Circulation Research

Circresaha 120 317703 fig07

Abstract

Rationale:

In addition to the overwhelming lung inflammation that prevails in coronavirus disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2. Platelets are chiefly implicated in thrombosis. Moreover, they can interact with viruses and are an important source of inflammatory mediators. While a lower platelet count is associated with severity and mortality, little is known about platelet function during COVID-19.


Objective:

To evaluate the contribution of platelets to inflammation and thrombosis in patients with COVID-19.


The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.318257