Basic Cardiovascular Science 2020 Scientific Sessions is supported by an independent medical education grant from: Merck and Novartis Pharmaceuticals North America.

The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a

Originally published 11 May 2020 | Circulation Research

2020 09 17 16 32 34

Abstract

Rationale:

Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has established that CircITCH (circular RNA ITCH [E3 ubiquitin-protein ligase]) is a broad-spectrum tumor-suppressive circular RNA and that its host gene, ITCH (E3 ubiquitin protein ligase), is involved in doxorubicin-induced cardiotoxicity (DOXIC). Whether CircITCH plays a role in DOXIC remains unknown.

The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316061.