May 11th, 2020

The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a

Dong Han, Yongjun Wang, Yabin Wang, Xinchun Dai, Tingwen Zhou, Jiangwei Chen, Bo Tao, Jibin Zhang, Feng Cao
Originally published 11 May 2020 | Circulation Research
2020 09 17 16 32 34

Abstract

Rationale:

Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has established that CircITCH (circular RNA ITCH [E3 ubiquitin-protein ligase]) is a broad-spectrum tumor-suppressive circular RNA and that its host gene, ITCH (E3 ubiquitin protein ligase), is involved in doxorubicin-induced cardiotoxicity (DOXIC). Whether CircITCH plays a role in DOXIC remains unknown.

The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316061.