Basic Cardiovascular Science 2020 Scientific Sessions is supported by an independent medical education grant from: Merck and Novartis Pharmaceuticals North America.

Self-Maintenance of Cardiac Resident Reparative Macrophages Attenuates Doxorubicin-Induced Cardiomyopathy Through the SR-A1-c-Myc Axis

Originally published 29 May 2020 | Circulation Research

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Abstract

Rationale:

Doxorubicin-induced cardiomyopathy (DiCM) is a primary cause of heart failure and mortality in cancer patients, in which macrophage-orchestrated inflammation serves as an essential pathological mechanism. However, the specific roles of tissue-resident and monocyte-derived macrophages in DiCM remain poorly understood.

The full text of this article can be found at: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316428.