Concurrent Session 1B | Cutting-Edge Approaches to Targeting Complex Cardiomyopathies

Moderator: Jil Tardiff, MD, PhD, Tucson, Arizona

1:00 pm

Drugs and HCM Mutations Modulating Myosin-Binding Protein C Binding to Actin Identified by a High-Throughput Fluorescence Lifetime-Based Assay

Brett Colson, PhD, Tucson, Arizona

1:15 pm       

Targeting Protein Degradation of Myosin Binding Protein C in the Context of Loss-of-Function Variants That Cause Hypertrophic Cardiomyopathy

Sharlene Day, MD, Ann Arbor, Michigan

1:30 pm       

Visualizing Metabolic Flux Remodeling in Diseased Hearts Using Stable Isotope Kinetics

Andrew Carley, PhD, Columbus, Ohio

1:45 pm       

Q&A